Since everyone metabolizes medications differently, the half-life will vary from person to person. For most people, oxycodone will fully clear the blood within 24 hours, but it can still be detected in the saliva, urine, or hair for longer than that. Controlled or extended-release formulations last longer, so they are usually taken every 12 hours. A number of factors can influence the time it takes for oxycodone to clear the body. These include:. The blood concentrations of oxycodone have been shown to be 15 percent higher in the elderly over age 65 compared to younger adults.
It may take longer for elderly people to clear oxycodone from their system. According to the package insert for OxyContin, oxycodone concentration for healthy female subjects was up to 25 percent higher than in males. The same was seen in studies for Xtampza ER.
The reason for this is unclear. The average half-life of oxycodone increases by 2. This means it will take longer to clear oxycodone from the body. One study found that the average half-life of oxycodone increases by one hour in people with kidney problems. If you take oxycodone regularly, it can accumulate in fatty tissues in your body. The effects of oxycodone are increased if you consume alcohol.
Not only will it take longer to clear oxycodone from your body, but it can also lead to dangerous side effects, including a potentially fatal overdose. Drugs that inhibit CYP3A4 make it more difficult for your body to break down oxycodone.
Taking oxycodone with the following medications could result in serious problems, including respiratory depression:. Withdrawal symptoms occur when the body has become dependent on a drug. Dependence is different from addiction. In drug dependence, the body has become used to the presence of a drug, so if you stop taking that drug suddenly, you will experience predictable symptoms known as a withdrawal symptoms.
Your doctor may reduce your dosage gradually over time to prevent withdrawal. This is called tapering. If you do experience withdrawal symptoms, they can be classified as mild, moderate, or severe. Everyone experiences withdrawal differently, but in general symptoms begin to improve within 72 hours and decrease significantly within a week.
Your doctor can help you manage your symptoms. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria PKU , or any other condition that requires you to reduce or avoid these substances in your diet.
Ask your doctor or pharmacist for safe use of this product. Older adults may be more responsive to the side effects of this drug, especially confusion, dizziness, somnolence, and slow breathing. This medicine should only be used during pregnancy when needed in urgent.
It could harm an unborn child. This medicine passes into breast milk and may have undesirable effects on a nursing infant. Tell your doctor if your child has the problem of unusual sleepiness, difficulty feeding, or difficulty breathing. Before breastfeeding, consult your doctor. Note: Do not share this medicine with others. It is against the law to share it. This medicine has only been prescribed for your current condition. Do not use it later for another condition unless your doctor tells you to do so.
Ask your doctor or pharmacist if you should have naloxone available to treat an overdose of opioids. Teach your family or household members about the signs of an overdose of opioid and how to treat it Missed Dose: If you are taking this medicine on a regularly scheduled basis and forget to take any dose, take it as soon as you remember it.
If it is near the next dosage time, skip the forgotten dose. Overdose: If someone has overdosed and has serious symptoms such as passing out or difficulty breathing, give them naloxone if available, then call the poison control center immediately.
Storage: Store protected from sunlight and moisture at room temperature. Different brands of this medicine have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist for instructions. Keep all drugs away from kids. Discard this product properly when it has expired or is no longer needed. For more details, please read the Medication Guide or consult your pharmacist or local waste disposal company.
Percocet vs Vicodin Percocet Vicodin Percocet oxycodone and acetaminophen is a combination drug consisting of an opioid Vicodin is a strong prescription pain medicine that contains an opioid This combination medicine is used to help relieve moderate to severe pain. Used to manage pain that is severe enough to require opioid pain medicine. Brand Name: Percocet Brand Name: Vicodin Generic Name: acetaminophen and oxycodone Generic Name: acetaminophen and hydrocodone Percocet contains a combination of acetaminophen and oxycodone.
Vicodin contains a combination of acetaminophen and hydrocodone Frequently Asked Questions:. What is Percocet used for? This combination medicine is used to help relieve moderate to severe pain. What type of pill is a Percocet? Percocet oxycodone and acetaminophen is a combination drug consisting of an opioid and a pain reliever and a fever reducer analgesic and antipyretic used for the management of moderate to severe pain, usually for a longer period of time.
You will be more likely to get side effects. Painkillers that contain codeine include co-codamol codeine and paracetamol , Nurofen Plus codeine and ibuprofen , co-codaprin codeine and aspirin and Solpadeine codeine, paracetamol, ibuprofen and caffeine. Like all medicines, oxycodone can cause side effects in some people, but many people have no side effects or only minor ones.
The higher the dose of oxycodone the more chance that you will get side effects. Common side effects happen in more than 1 in people. Talk to a doctor or pharmacist if these side effects bother you or do not go away:. Serious side effects happen in less than 1 in people. Call a doctor if you have:. In rare cases, it's possible to have a serious allergic reaction anaphylaxis to oxycodone.
These are not all the side effects of oxycodone. For a full list, see the leaflet inside your medicine packet. Do not take any other medicines to treat the side effects of oxycodone without speaking to a pharmacist or doctor first. Oxycodone is generally not recommended during pregnancy or while breastfeeding. In early pregnancy, it's been linked to some problems for your baby. If you take oxycodone at the end of pregnancy there's a risk that your baby may get withdrawal symptoms or be addicted to oxycodone when they're born.
However, it's important to treat pain in pregnancy. For some pregnant women with severe pain, oxycodone might be the right medicine. Your doctor is the best person to help you decide what's right for you and your baby.
Oxycodone is not usually recommended if you're breastfeeding. Small amounts of oxycodone pass into breast milk and may cause breathing problems for your baby. Tell a doctor if you are breastfeeding. They may be able to recommend a different painkiller. Some medicines and oxycodone interfere with each other and increase the chance that you will have side effects. Tell a doctor before you start taking oxycodone if you are taking any medicines:. It's not possible to say that oxycodone is safe to take with herbal remedies and supplements.
They're not tested for the effect they have on other medicines in the same way pharmacy and prescription medicines are. Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. It works in the central nervous system and the brain to block pain signals to the rest of the body. It also reduces the anxiety and stress caused by pain. This depends on the type of oxycodone you take — fast acting or slow acting.
Fast-acting oxycodone capsules and liquid take 30 to 60 minutes to work, but these wear off after 4 to 6 hours. Slow-acting oxycodone tablets can take 1 to 2 days to work fully, but the pain relief will last longer. An oxycodone injection into a vein gives the quickest pain relief and works almost straight away. Depending on why you're taking oxycodone, you may only need to take it for a short time. For example, if you're in pain after an injury or operation, you may only need to take oxycodone for a few days or weeks at most.
You may need to take it for longer if you have a long-term condition such as cancer. It is possible to become addicted to oxycodone. If you need to take if for a long time your body can become tolerant to it. That means you need higher doses to control your pain over time.
For this reason, the dose you take will be reviewed to make sure you are only taking the amount you need to control your pain. If you're addicted to oxycodone, you may find it difficult to stop taking it or feel you need to take it more often than necessary. If you stop taking it suddenly you may suffer from withdrawal symptoms. These include:.
Talk to a doctor if you're worried about addiction or if you want to know more about how to prevent withdrawal symptoms. For some people with conditions who need long-term pain relief, it may be necessary to take oxycodone for a long time.
If you need to take it for a long time, your body can become tolerant to it. Some people can become more sensitive to pain hyperalgesia. If this happens, your doctor will reduce your dose gradually to help these symptoms. For this reason, your dose will be reviewed to make sure you are only taking the amount you need to control your pain. Your treatment plan may include details of how and when you will stop taking oxycodone. If you are having treatment for cancer pain or other severe pain, your pain control will be carefully monitored.
Speak to your doctor if you are worried about tolerance, hyperalgesia or becoming addicted. If you need to take oxycodone for a long time, your body can get used to it. This is not usually a problem, but if you stop taking it suddenly you could get withdrawal symptoms such as:. If you want to stop taking oxycodone, talk to a doctor first.
Your dose can be reduced gradually so you do not get these symptoms. Oxycodone acts on different pain signals in the brain to some other opiates. This does not mean it's better for certain conditions. The pain relief and side effects which you can get from oxycodone will be different for individual people. A doctor may prescribe oxycodone if you have had side effects from other opiates. It's best to stop drinking alcohol during the first few days of treatment, or if a doctor increases your dose, until you see how oxycodone affects you.
Drinking alcohol while you're taking oxycodone may make you feel more sleepy or increase the risk of serious side effects. Grapefruit juice can increase the amount of oxycodone in your body so it's a good idea to avoid it while you're taking oxycodone.
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